Dna is a potential target for oxidative damage and genomic damage can contribute to neuropathogenesis it is important therefore to identify tools for the quantitative analysis of dna damage in models on neurological disorders this book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. Thus oxidative stress elicits various neurodegenerative diseases in addition chemotherapy could result in severe side effects on the cns and peripheral nervous system pns of cancer patients and a growing body of evidence demonstrates the involvement of ros in drug induced neurotoxicities as well. Oxidative insults whether over excitation excessive release of glutamate or atp caused by stroke ischemia or inflammation exposure to ionizing radiation heavy metal ions or oxidized lipoproteins may initiate various signaling cascades leading to apoptotic cell death and neurodegenerative disorders. Oxidative stress and the pathogenesis of neurodegenerative disorders i introduction free radicals immunity and the nervous system cells within the brain notably neurons are highly ii neuropathogenesis of neurodegeneration ad is the most common neurodegenerative disease sporadic ad is